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For three months rat livers absorbed coal dust containing low or high concentrations of heavy metals. We found that these concentrations of heavy metals significantly decrease cytochrome P-450 content in hepatic microsomes, and that this decrease correlates with the concentration of heavy metals. Furthermore, we have shown that only coal dust with high heavy metal content produces such structural...
We evaluated morphological changes, the activities of succinate dehydrogenase, lactate dehydrogenase, glucose-6-phosphatase, Mg2+ -dependent adenosine triphosphatase, and acid phosphatase, and the activity of the cytochrome P-450-dependent monooxygenase system in the kidneys of rats exposed to coal dusts containing either very low or high amounts of heavy metals. We showed that the coal dust with...
We evaluated morphological changes, the activities of succinate dehydrogenase, lactate dehydrogenase, glucoso-6-phosphatase, Mg2+-dependent adenosine triphosphatase, and acid phosphatase, and the activity of the cytochrome P-450-dependent monooxygenase system in rat kidneys exposed to coal dusts containing either low or high amounts of heavy metals. We showed that the coal dust with a very low content...
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