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Functional studies have provided evidence supporting the concept that the tridecapeptide neurotensin (NT) acts in the central nervous system as a classical neurotransmitter and/or as an important modulator of neuronal signalling. The role of NT in the regulation of the striatal aminoacidergic transmission, mainly by antagonising D2 receptor function, will be analysed. In addition, in different rat...
Stimulation of dopamine D 1 -receptors by SKF 82958 increased extracellular neurotensin (NT) levels in the striatum and nucleus accumbens as measured by in vivo microdialysis while blockade of D 1 -receptors had no effect. Antagonism of NMDA receptors with MK 801 completely prevented the increased NT release induced by D 1 -stimulation in both structures. Tissue content of...
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