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A rat four-vessel cerebral occlusion model was used to examine the effects of d-lactate and oxamate, a lactate dehydrogenase inhibitor, on cortical window superfusate levels of amino acids, glucose and l-lactate. Superfusate levels of aspartate, glutamate, taurine, GABA and phosphoethanolamine rose during ischemia and then declined during reperfusion. Glycine and alanine levels tended to increase...
Brain tissue acidosis is considered to be a contributor to ischemic brain injury. The deleterious effects of marked acidosis may be associated with reperfusion and an excessive entry of Na + into cerebral neurons and glia as intracellular pH is restored by Na + /H + exchange. Normalization of pH, with activation of many calcium-dependent and other phospholipases and proteases...
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