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Urate and ascorbate play a major role in the defense mechanism of the brain against oxidative damage induced by traumatic brain injury. The severity and extent of brain damage are known to increase with age. This may be due to different basal levels of endogenous antioxidants, and/or to impaired ability of the old brain to recruit and elevate the levels of antioxidants following injury. To investigate...
Skin is one of the tissues most exposed to oxidative stress both from endogenous and exogenous sources. Therefore, it can be speculated that skin possesses an extremely efficient antioxidant defense mechanism, particularly in its epidermal layers. The present study shows that human and rat skins possess different and unique reducing antioxidant profiles. These reducing antioxidants can be washed out...
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