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Compact measurement setup and test structure for nanosecond electroporation of biological cells were demonstrated. The test structure was based on a coplanar waveguide with a defected ground structure that afforded broadband impedance match with little dispersion or parasitic. The defected ground structure with a 10-µm gap formed a microchamber to readily accept biological solutions and to allow the...
Nanosecond electroporation has a range of applications including gene therapy and treatment of melanoma tumors. On applying a nanosecond high voltage pulse, potential differences are generated across the membranes of the internal organelles resulting in its electroporation. This paper investigates the effect of nanosecond high voltage pulses simulated on a biological cell placed in a conductive medium...
In order to model nanosecond pulse electroporation of the cell membrane the effect of dielectric relaxation of membrane molecules has to be considered. Since the formation of pores is a nonlinear process the dielectric relaxation effects have to be incorporated as dispersion in the time-domain. This paper presents the time-domain implementation of a second-order Debye dispersion model for a single-shell...
The initial response of a cell to an applied electric field is determined by its dielectric properties. Conversely, exposure to an electric field can alter these parameters. Hence, an understanding of dielectric membrane phenomena helps in explaining the underlying interaction mechanisms. Moreover, different electrical characteristics might also allow devising exposure conditions for pulsed electric...
Electrical models for biological cells predict that reducing the duration of applied electrical pulses to values below the charging time of the outer membrane causes a strong increase in the probability for electric field interactions with intracellular structures. For electric field amplitudes exceeding MV/m, such pulses are expected to cause electroporation of cell organelles, with the required...
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