The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Primary immune responses are initiated when foreign pathogenic microorganisms move past the front-line defense system of the body. The primary immune responses consist of a) the production of antibody molecules that are specific for the pathogenic microorganism and b) the expansion and differentiation of special-purpose defensive cells, the lymphocytes. In this scenario, our work aims to develop and...
Computational models for cardiomyocyte action potentials (AP) often make use of a large parameter set. This parameter set can contain some elements that are fitted to experimental data independently of any other element, some elements that are derived concurrently with other elements to match experimental data, and some elements that are derived purely from phenomenological fitting to produce the...
The electrical activation sequence of the ventricles follows a complex pattern which ensures an efficient contraction and subsequent blood pumping. Today, electrical therapies are often used to correct those behaviors, although a-priori it is unknown how the activation sequence will change. In this paper, we study changes in the activation pattern using electrical simulations based on both phenomenological...
Animal studies have shown that chronic stress and depression produce irreversible atrophy of the apical dendrites of CA3 pyramidal neurons. Dysregulations caused by depression also disturbes molecular mechanisms of hippocampal long-term potentiation (LTP). The effect of stress on amygdala is just the opposite of the hippocampus; neuroimaging studies have found both increased baseline activity and...
Extra-cellular signal regulated kinase (ERK) signal transduction is an important signaling pathway, involved in a variety of processes in cell and closely related to the occurrences of diverse tumors. This raises the question how these diverse functions are specified and coordinated. In this work, we present an integrated computational model of ERK signal transduction pathway, investigating the regulatory...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.