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The variable conductance of postsynaptic membrane of neuron dependence on the acetylcholine-receptor binding activity is represented by enzyme modified field effect transistor (ENFET) sensitive to acetylcholine. Acetylcholine sensitive ENFET functions not only as a voltage controlled conductance but can also provide a means of measurement of specific neurotransmitters that bind with the receptor sites...
This paper discusses the implications of noises in a pulse-density modulation single-electron circuit based on vestibulo-ocular reflex model. The proposed circuit consists of an ensemble of single-electron integrate-and-fire neurons that encode the input voltage into pulses whose temporal density is proportional to the amplitude of the input. We confirmed that static noises (heterogeneity in circuit...
The Mihalas-Niebur neural model is a generalized model of the leaky integrate-and-fire neuron with adaptive threshold. It has been shown in simulation to be capable of producing most of the known spiking and bursting patterns of cortical neurons. We present results from the first circuit implementation of the model with six spiking patterns observed in biological regular-spiking, fast-spiking and...
This paper presents an original method to adjust parameters for a neuromimetic IC based on neuron conductance-based models (Hodgkin-Huxley formalism). To adjust the chip, we use a Metaheuristic, the Differential Evolution algorithm (DE). We detail the DE for its implementation in our hardware neural simulator. The DE estimates in the same time all the parameters of one ionic channel. We discuss about...
Carbon nanotubes vertically aligned to the surface of microtransducers such as metal microelectrodes or FET-based devices are proposed as electrical interfaces to neurons. A model of such a system is developed to simulate the induced extracellular neuronal electrical activity. The results brought out nanotubes act on the amplitude and the shape of the extracellularly recorded signals and promote an...
Carbon nanotubes vertically aligned to the surface of microtransducers such as metal microelectrodes or FET-based devices are proposed as electrical interfaces to neurons. A model of such a system is developed to simulate the induced extracellular neuronal electrical activity. The results brought out nanotubes act on the amplitude and the shape of the extracellularly recorded signals and promote an...
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