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Free radicals, including dopamine (DA)-oxidized metabolites, have long been implicated in pathogenesis of Parkinson’s disease (PD). However, the relationships between such oxidative stresses and α-synuclein (α-S), a major constituent of Lewy bodies, remain unknown. In this study, we established neuronal cells that constitutively express α-S and tetracycline-regulated tyrosinase. While tyrosinase overexpression...
We present for discussion a possible molecular mechanism explaining the formation of reactive oxygen species involved in the neurodegenerative process of dopaminergic system in Parkinson’s disease. This new hypothesis involves one-electron reduction of aminochrome too-semiquinone radical, which seems to be the reaction responsible for neurodegenerative process of dopaminergic system. Leukoaminochrome...
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