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Osteoporosis has been widely known as a reoccurring issue with the increase of age. By understanding key mechanical properties of bone, researchers can better understand methods to induce bone growth as a possible method for osteoporosis reversal. This study uses image modeling to characterize the natural frequency of normal bone by using Finite Element Methods (FEM). Results indicate that the natural...
To diagnose the osteoporosis accurately, the bone mineral density (BMD) measurements of the vertebral bodies (VBs) are required. In this paper, we propose a new segmentation and registration method in order to assist the BMD measurements and fracture analysis (FA) accurately. In this experiment, image appearance and shape information of VBs are used. Our shape model is required to be registered to...
Bone fragility involved in diseases such as osteoporosis implicates many mechanisms at the cellular level. It was recently shown that the lacunar-canalicular network interconnecting osteocytes has a major role in mechanosensitivity. So far, this system has only been studied from 2D microscopic images. In a previous work, we demonstrated the feasibility of synchrotron radiation micro-CT with a voxel...
Summary form only given. The mechanical competence of a bone depends on its density, its geometry and its internal trabecular microarchitecture. The gold standard to determine bone competence is an experimental, mechanical test. Direct mechanical testing is a straight-forward procedure, but is limited by its destructiveness. For the clinician, the prediction of bone quality for individual patients...
The use of ultrasound as an alternative diagnostic ldquoscreeningrdquo tool for osteoporosis has extensively been studied. One ultrasound parameter that has shown promise is the speed-of-sound (SOS) as it has been correlated experimentally to bone strength. Unfortunately, to date, a complete mechanical understanding of these findings is still missing. The aim of this study was therefore to look into...
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