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In order to determine the state of dopamine (DA) derived from exogenously administered l-3,4-dihydroxyphenylalanine (l-DOPA) in the striatum of Parkinson's disease, we have applied an in vivo brain microdialysis method to rats with dopaminergic denervation with 6-hydroxydopamine (6-OHDA), the rat model of Parkinson's disease, and measured extracellular DA levels in the striatum after l-DOPA administration...
In vivo microdialysis was used to examine the effects of dopaminergic transplants on extracellular concentrations of dopamine (DA), serotonin (5-HT), and their precursors and major metabolites in the denervated rat striatum. Dialysis perfusates were collected from intact, 6-hydroxydopamine (6-OHDA) lesion plus sham grafted, and lesion plus fetal substantia nigra (SN) grafted striata. The SN transplants...
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