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Alterations of striatal cholinergic markers may correlate with cognitive impairments in aged rats. M2 muscarinic receptors were found to be presynaptic inhibitory autoreceptors on striatal cholinergic interneurons. The effect of bilateral intrastriatal infusions of the M2 muscarinic receptor antagonist methoctramine was assessed, in cognitively impaired aged (24-26 months) Long-Evans female rats,...
It is well known that learning and memory ability declines with aging. Age-related long-term changes in learning and memory ability in rats were investigated with the place navigation task and the allocentric place discrimination task (APDT) in a water maze using the same animals for each task. In a working memory place navigation task, aged animals could learn the location of the platform as well...
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