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We report a novel sandwich type assay for the optical detection of DNA using multi-component crosslinked Au nanoparticle aggregates. In this design, a DNA bridged multi-functional Au nanoparticle aggregate, which integrates DNA recognition (detection probe), signal amplification (enzyme, horseradish peroxidase) and non-specific blocking (bovine serum albumin, BSA) section, is employed as detection...
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