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The disease burden related to diabetes is high and rising in every country, fuelled by the global rise in the prevalence of obesity and unhealthy lifestyles. The latest estimates show a global prevalence of 382 million people with diabetes in 2013, expected to rise to 592 million by 2035. The aetiological classification of diabetes has now been widely accepted. Type 1 and type 2 diabetes are the two...
The rising prevalence of type 2 diabetes around the world and the global pattern of variation in risk between countries have been widely attributed to an interplay between rising rates of obesity and poor lifestyles, and genetic or developmental susceptibility to disease. Although this general hypothesis has been in existence for more than 50 years, the precise mechanisms that may explain it have...
Diabetes is a chronic disorder of glucose metabolism, associated with microvascular (retinopathy, nephropathy, neuropathy) and macrovascular (angiopathy with increased risk of ischaemic heart disease and stroke) complications, as well as premature mortality. There are two main aetiological types of diabetes. Type 1 diabetes classically occurs in children and young adults, and is related to an absolute...
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