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Acute or sustained stretch of cardiac tissue is known to play a key role in arrhythmogenesis. Using a fluorescence approach, we designed a system measuring calcium transients and transmembrane potential changes in monolayers of cultured cardiomyocytes under uniaxial elongation and electrical stimulation. Cardiac myocytes are seeded on a rectangular PDMS template held and stretched by a motorized linear...
The authors have been engaged in the study of countermeasures to prevent the leak of onscreen movies using a digital video camera. One of the studies is the development of a transparent sheet that emits infrared (IR) light, which is applied to the screen and generates optical noise in the onscreen photographic images when recorded. Another study is the development of a method to detect the presence...
This paper presents a novel yet high-performance diascopic illumination configuration for simultaneously detecting cells of different sizes and different fluorescence labeling in a microfluidic chip. An objective-type dark-field condenser equipped with a low-cost tungsten bulb light source with continuous wavelengths (400 to 900 nm) and an UV-Vis-NIR spectrometer is used for detecting the multispectral...
Microfluidics has made great progress in integrating many aspects of biological analysis and testing into the microscale. One aspect which has proven challenging to miniaturize has been fluorescence testing, as a complete fluorescence system requires an integrated light source, detector and filters to filter out the excitation light (from the light source) from the detector. Here we demonstrate that...
This paper presents a novel yet high performance diascopic illumination configuration for simultaneously detecting cells of different sizes and different fluorescence labeling in a microfluidic chip. An objective-type dark-field condenser equipped with a low-cost tungsten bulb light source with continuous wavelengths (400 to 900 nm) and an UV-Vis-NIR spectrometer is used for detecting the multispectral...
Optical Coherence Tomography (OCT) is a well known technique for creating non-invasive, high resolution images of biological microstructure. OCT has matured into animportant imaging modality since its invention in 1991. The popularity of the method lies in the numerous advantages that it offers high detection sensitivity allowing fast imaging speed, andhigh spatial resolution. In this paper we propose...
Summary form only given. We consider two resonant molecules (or nano-particles) located near the tip of an apertureless near-field scanning optical microscope (NSOM). The tip serves as a probe that allows us to observe the molecules and control the coupling between them. Various models are considered for the nanosized probe tip: a point-like dipole, a small dielectric sphere, and an elongated spheroidal...
Summary form only given. A single fluorescent molecule in an isotropic medium acts as a dipole radiator. In a locally heterogeneous environment the angular emission pattern is modified. Recently Novotny (1996) calculated strongly peaked angular emission when the emitter is brought in close proximity to a strong dielectric-metal gradient. We believe we present the first direct observation of this prediction;...
Summary form only given. With the advent of scanning near-field optical microscopy (SNOM) ultrahigh-resolution optical microscopy has attracted renewed interest. Although after more than a decade the conventional mode of SNOM that uses a subwavelength aperture has bottomed out at a resolution of roughly 50 nm, an unlimited resolution could be expected in optical near-field microscopy. One of the conceptually...
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