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Over the past three decades, at least 10 hormones secreted by the enteroendocrine cells have been discovered, which directly affect the cardiovascular system through their innate receptors expressed in the heart and blood vessels or through a neural mechanism. Glucagon‐like peptide‐1 (GLP‐1), an important incretin, is perhaps best studied of these gut‐derived hormones with important cardiovascular...
Glucagon‐like peptide‐1 receptor (GLP‐1R) agonists have been shown to regulate blood glucose concentrations by mechanisms including enhanced insulin synthesis/secretion, suppressed glucagon secretion, slowed gastric emptying, and enhanced satiety. GLP‐1 receptors have also been identified in the heart, kidneys, and blood vessels, leading to the hypothesis that GLP‐1R agonists may affect cardiovascular...
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