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Sonoporation refers to using ultrasound on microbubbles to induce cavitation so that the permeability of cellular membrane can be enhanced. Enhanced permeability can thus increase the delivery efficiency of therapeutic agents into the cells. In this study, we use gold nanorods (AuNRs) as the therapeutic agent of plasmonic photothermal therapy (PPTT) for tumor treatment. Increased delivery efficiency...
Gold nanorods (AuNRs) have been used as contrast enhancement agents for photoacoustic (PA) imaging as well as effective photothermal therapy agents. In the literature, pulsed ultrasound exposures have shown to enhance delivery of fluorescently labeled polystyrene nanoparticles. Microbubbles (MBs) can also substantially enhance the ablation effects. In this study, we develop a US/PA imaging/therapeutic...
Cryoablation is a minimally invasive ablation technique for primary and metastatic hepatic tumors. Inadequate freezing around large blood vessels due to the warm blood flow can lead to local recurrence, and thus, necessitates close application of a cryoprobe to the large blood vessels. In this study, we constructed a perfusion model with an exvivo bovine liver and ablated the tissue around a large...
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