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Vibrational spectroscopy (Raman and FTIR microspectroscopy) is an attractive modality for the analysis of biological samples since it provides a complete non-invasive acquisition of the biochemical fingerprint of the sample. Studies in our laboratory have applied vibrational spectroscopy to the analysis of biological function in response to external agents (chemotherapeutic drugs, ionising radiation,...
Microarray technology has been widely applied to search for biomarkers of diseases, diagnose diseases and analyze gene regulatory network. Abundance of expression data from microarray experiments are processed by informatics tools, such as supporting vector machines (SVM), artificial neural network (ANN), and so on. These methods achieve good results in single dataset. Nevertheless, most analyses...
Human mitochondrial proteins are involved in fundamental biological process including apoptosis, energy production and many metabolic pathways, prediction of mitochondrial proteins is a major challenge in genome annotation. In this study, we implemented a machine learning approach and developed reliable neural network and SVM based methods to classify human mitochondria proteins with high confidence...
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