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The last 20 years have seen the development of fetal surgery, particularly for the treatment of twin-to-twin transfusion syndrome (TTTS). Although fetoscopy increases survival rate, it is also invasive and responsible for fetal and maternal complications affecting the neonatal outcome. A completely non-invasive treatment that could occlude deep anastomoses would prevent the risks of invasive fetoscopy...
The ability to visualize breast lesion vascularity and quantify the vascular heterogeneity using contrast-enhanced 3-D nonlinear ultrasound imaging was investigated in a clinical population. Patients (n = 236) identified with breast lesions on mammography were scanned using power Doppler imaging, contrast-enhanced 3D HI, and 3D SHI on a modified Logiq 9 scanner (GE Healthcare). Time-intensity curve...
The manual outlining of hepatic metastasis in (US) ultrasound acquisitions from patients suffering from pancreatic cancer is common practice. However, such pure manual measurements are often very time consuming, and the results repeatedly differ between the raters. In this contribution, we study the in-depth assessment of an interactive graph-based approach for the segmentation for pancreatic metastasis...
In recent years, HIFU (High Intensity Focused Ultrasound) therapy, which is one of the non-invasive therapies utilizing focused ultrasound, have attracted a great attention as a novel treatment method for a focal lesion, such as a tumor and a stone. However, the focal lesion moves in accordance with respiration, which may cause the damage for the surrounding normal tissues. To cope with this problem,...
Breast ultrasound is an important complement to mammography that allows differentiating between benign and malignant lesions. The early diagnosis and specialized care for women with breast cancer are indispensable for a better therapeutic result and prognosis of cases. Thereby, it is necessary training professionals to emit trustworthy diagnoses. Here, we set up lesions-like structures in a plasticized...
Accurate segmentation of breast lesions is among the several challenges in the development of a fully automatic Computer-Aided Diagnosis system for solid breast mass classification. Many high level segmentation methods rely heavily on proper initialization and the seed point selection is usually the necessary first step. In this paper, a fully automatic and robust seed point selection method is proposed...
Breast cancer is one of the main causes of women mortality worldwide. Ultrasonography (USG) is other modalities than mammography that capable to support radiologists in diagnosing breast cancer. However, the diagnosis may come with different interpretation depending on the radiologists experience. Therefore, Computer-Aided Diagnosis (CAD) is developed as a tool for radiologist's second opinion. CAD...
One of the imaging modalities for early detection of breast cancer is ultrasonography (USG). The detection is based on lesions identification. Radiologists still manually conduct early detection of the lesions. Hence, the detection results tend to be subjective and may cause different interpretations due to the different level of knowledge and experience of the radiologists. In this research, the...
The ability to visualize breast lesion vascularity and quantify the vascular heterogeneity using contrast-enhanced 3-D nonlinear ultrasound imaging was investigated in a clinical population. Patients (n = 236) identified with breast lesions on mammography were scanned using power Doppler imaging, contrast-enhanced 3D HI, and 3D SHI on a modified Logiq 9 scanner (GE Healthcare). Time-intensity curve...
This paper proposes a general boundary delineation method for 2D serial US images by modeling the spatial-temporal dynamics and generating the object boundary in each slice under the cell-based MAP scheme. The modeling of the spatial-temporal dynamics can serve as a prior to guide the cell-based MAP process and potentially maintain the contextual coherence. Experiments have been conducted on 8 sets...
Here we report in-vivo validation of a fusion modeling method which associates real in-vivo motion data acquired from ultrasound speckle tracking imaging and data from a multi-scale modeling tool. This method aims at estimating the impact of in-vivo liver motion on High Intensity Focused Ultrasound (HIFU) treatments by quantifying thermal lesion deformations. A Dice Similarity Coefficient (DSC) was...
Hepatocellular carcinoma is one of the fastest growing cancers worldwide. Histotripsy is a non-invasive ablation method that fractionates soft tissue through the control of acoustic cavitation. In this study, we demonstrate the feasibility of using histotripsy for non-invasive liver ablation. Fourteen ∼1cm3 lesions were created in the livers of eight pigs through the intact chest in vivo without using...
Breast cancer is the fifth most common cause of cancer death and most common cancer among women [14]. With advances in screening, diagnosis, and treatment, the death rate for breast cancer has declined by about 20% over the past decade. Micro-calcifications are calcium deposit which can be identified as tiny areas that are slightly brighter than surrounding tissue [13]. In this paper, we propose a...
Worldwide, breast cancer is the fifth most common cause of cancer death and is the most common cancer among women [14]. With advances in screening, diagnosis, and treatment, the death rate for breast cancer has declined by about 20% over the past decade. Micro-calcifications are calcium deposit, which can be identified as tiny areas that are slightly brighter than surrounding tissues [13]. In this...
The present study provides preliminary data of the usefulness of elastography applied in intraoperative pancreatic ultrasound for diagnosis and staging of pancreas tumors. We have studied six cases of pancreatic tumors, four adenocarcinomas and one insulinoma, which have been submitted to surgery. Tumor resection was considered based on preoperative evaluation and also in intraoperative findings....
Acoustic droplet vaporization (ADV) is an ultrasound method for converting biocompatible microdroplets into microbubbles. The objective is to demonstrate that ADV bubbles can enhance high intensity focused ultrasound (HIFU) therapy by controlling and increasing energy absorption at the focus. Thermal phantoms were made with or without droplets. Compound lesions were formed in the phantoms by 5-second...
A technique for improvement of ultrasonic B-mode imaging that uses coded excitation, pulse compression, and frequency compounding was developed. A coded excitation and pulse compression technique known as resolution enhancement compression (REC) was used to enhance the bandwidth of an imaging system by a factor of two. This bandwidth was subdivided into smaller subbands through the speckle-reducing...
This study assessed the utility of machine learning for isolating noise and artifacts in breast ultrasound images. Such corrupt image regions (ROIs) can be automatically excluded when registering images acquired from different angles. Artifacts included posterior acoustic shadowing and enhancement arising from cancers and cysts respectively. Images were obtained on a breast-mimicking phantom containing...
Supersonic Shear Imaging (SSI) is a quantitative stiffness imaging technique based on the combination of a radiation force induced in tissue by an ultrasonic beam and ultrafast ultrasound imaging sequence (up to more than 10000 frames per second) catching in real time the propagation of the resulting shear waves. Local shear wave speed is estimated and enables the two dimensional mapping of shear...
Harmonic Motion Imaging (HMI) is a technique capable of imaging tissue mechanical properties during acoustic radiation force application. Recently, HMIFU has been shown capable for high-intensity focused ultrasound (HIFU) therapy and monitoring. Here, a theoretical analysis of the Harmonic Motion Imaging for Focused Ultrasound (HMIFU) system is performed using a 2D nonlinear wave propagation model...
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