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Bone seeking radiopharmaceutics are often used in patients with skeletal lesions during the diagnostic and, less frequently, the therapeutic setting. The aim of the radionuclide therapy in patients with bone metastases is to release the maximum of the energy on neoplastic cells, with the minimum of toxicity for the remnant bone cells and extracellular environment. The radionuclides used in nuclear...
Le pronostic du cancer de prostate métastatique est multifactoriel. Un des facteurs déterminant de la survie est l’apparition de complications osseuses en relation avec la progression tumorale. Les stratégies thérapeutiques sont multiples : action locale par la radiothérapie voire la chirurgie des métastases osseuses ; action systémique par le traitement hormonal, la chimiothérapie et les amino bisphosphonates...
Résumé: La constatation que le récepteur EGF (Epidermal Growth Factor Receptor) et PDGFR (Platelet- Derived Growth Factor Receptor) sont impliqués dans les métastases osseuses ouvre de nouvelles perspectives thérapeutiques. Il s’agit d’une nouvelle approche qui devrait permettre le développement de nouveaux agents thérapeutiques que sont les inhibiteurs EGFR/HER2 et les antagonistes de PDGFR.
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