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The mechanisms of white matter (WM) damage during secondary degeneration are a fundamental issue in the pathophysiology of central nervous system (CNS) diseases. Our main goal was to describe the pattern of an acute inflammatory response and secondary damage to axons in different WM tracts of acutely injured rat spinal cord. Adult rats were deeply anesthetized and injected with 20 nmol of NMDA into...
The lengths of uncompacted and partly compacted oligodendroglial sheaths in the developing rat spinal cord (SC) ventral funiculus (ages F19 and F21) and corpus callosum (CC; ages P12 and P17) were studied by serial section electron microscopy. The average newly formed uncompacted sheath is 21 and 33 μm long in the SC (F19) and CC (P12), respectively, many being less than 10 μm. In these early series,...
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