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In man, i) arteries calcify with age and ii) age-linked arterial calcification is amplified by vascular pathology such as hypertension or arteriosclerosis. Age-linked arterial calcification has a bad prognosis but drugs to prevent it are lacking. This is partially due to the lack of appropriate animal models. This paper looks at the extent to which arteries calcify with age in the rat and whether...
This experiment was carried out on male Wistar rats aged 6, 12, and 24 months in two seasons, autumn and winter. In all age groups, the activity of Mg-dependent ATP-ase (Mg2+ -ATPase) showed rhythmic oscillations with a 12-hour period. A similar time course was observed for 12-hour variations in Mg and Ca concentrations. In both seasons the maxima of ATP-ase Mg activity paralleled the maxima of Mg...
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