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In the context of modeling epilepsy and neuropsychiatric comorbidities, we review the Wistar Audiogenic Rat (WAR), first introduced to the neuroscience international community more than 25years ago. The WAR strain is a genetically selected reflex model susceptible to audiogenic seizures (AS), acutely mimicking brainstem-dependent tonic–clonic seizures and chronically (by audiogenic kindling), temporal...
Epilepsy is the second-most prevalent neurological disorder after migraine and affects 1-2% of the world population. Epilepsy is a spectrum of disorders defined by the occurrence of epileptic seizures, which are characterized by the abnormal firing of large populations of neurons. Epilepsies can have a genetic component (as a direct cause or as risk factor) or can be triggered by a brain insult (including...
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