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Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related mortality, but its genetic etiology is largely unknown and likely complex involving multiple genes. The Kcna1 gene encodes Kv1.1 potassium channels that act to dampen neuronal excitability whereas the Scn2a gene encodes Nav1.2 sodium channels important for action potential conduction. We tested the hypothesis that...
Mice deficient for the gene encoding the RNA‐binding protein CELF4 (CUGBP, ELAV‐like family member 4) have a complex seizure phenotype that includes both convulsive and non‐convulsive seizures, depending upon gene dosage and strain background, modeling genetically complex epilepsy. Invertebrate CELF is associated with translational control in fruit fly ovary epithelium and with neurogenesis and neuronal...
Identification of the genes underlying psychiatric illness remains a thorny problem. Previously, Quantitative Trait Loci (QTL) for anxiety-like behaviors and β-carboline-induced seizure vulnerability have been mapped to the distal portion of mouse chromosome 10, with crosses of A/J and C57BL6 mice.An interval specific congenic strain for this chromosomal 10 region facilitated the genetic dissection...
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