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In guideline E14, the American Food and Drug Administration (FDA) requests for clinical studies to investigate the prolongation of the heart rate corrected QT-interval (QTc) of the ECG. As drug induced QT-prolongation can be caused by changes in the repolarisation of the ventricles, it is so far a thorough ECG biomarker of risk for ventricular tachyarrhyth-mias and Torsade de Pointes (TdP). Ventricular...
There is a large interest in analysing the QT-interval, as a prolonged QT-interval can cause the development of ventricular tachyarrhythmias such as Torsade de Pointes. One major part of QT-analysis is T-end detection. Three automatic T-end delineation methods based on wavelet filterbanks (WAM), correlation (CORM) and Principal Component Analysis PCA (PCAM) have been developed and applied to Physionet...
The QT interval is the lead biomarker for predicting risk of severe ventricular pro-arrhythmia in drug safety assessment. QT is a weak predictor, with no direct link to clinical endpoints.We propose two methods that might bridge the gap. Method A is based on the study level probabilistic intra-subject clustering of 12-lead based ECG waveform similarities, comparing pre-treatment with placebo and treatment...
This paper proposes the Stationarity Index, a measure of the similarities of the auto correlation integral of a section of a time series and the cross correlation of that section with others of the same time series. This measure of similarity is a measure of the stationarity of the time series and therefore can be used not only to detect nonstationarity but to also quantify it. The index is then successfully...
The QTc interval plays an important role in premarket testing of new drugs, but the intrinsic variability of the measurement is critical. Most arrhythmogenic drugs inhibit the IKr current and cause both QTc prolongation and changes in T-wave morphology. Quantification of T-wave morphology may be useful in drug testing, but no robust method exists for this purpose. We present a method for quantification...
Aim of the study was to assess the effect of the adrenergic stimulation on the dynamic of atrial signals (AS) during atrial fibrillation (AF). The AS, derived from surface ECG after having removed ventricular activity, were analyzed using the detrended fluctuation analysis. A sympathomimetic drug, the isoproterenol mimicking adrenergic activation, was administered in 13 patients with paroxysmal or...
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