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Our understanding of ADAM10 function has undergone a striking evolution during the past 10 years. After its independent identification in the bovine brain (then termed MADM) and invertebrates (sup-17 in Caenorhabditiselegans and kuzbanian in Drosophila melanogaster) it was first characterized as a key player in the Notch pathway in both flies and nematodes and as a candidate Amyloid Precursor...
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