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The signaling lipid sphingosine 1‐phosphate (S1P) plays key roles in many physiological processes. In the immune system, S1P's best‐described function is to draw cells out of tissues into circulation. Here, we will review models of S1P distribution in the thymus, lymph nodes, spleen, and nonlymphoid tissues. These models have been challenging to construct, because of the lack of tools to map lipid...
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