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Deep Brain Stimulation (DBS) is an effective treatment for patients with Parkinsons disease, but its impact on basal ganglia nuclei is not fully understood. DBS applied to the subthalamic nucleus (STN) affects neurons in the Globus Pallidus pars interna (GPi) through direct projections, as well as indirectly through the Globus Pallidus pars externa (GPe). Since traditional statistical analyses of...
Striatum (STR) is the major input stage of the basal ganglia (BG). It combines information from cortex, subthalamic nucleus (STN) and external globus pallidus (GPe), and projects to the output stages of the BG, where selection between concurrent motor programs is performed. Parkinson's disease (PD) reduces the concentration of dopamine (DA, a neurotransmitter) in STR and changes in the level of DA...
Deep brain stimulation is an effective therapy for Parkinson's disease (PD) that has enabled microelectrode recordings from single-unit cells in the sub-thalamic nucleus (STN) of the basal ganglia. This rare data is important to develop detailed characterizations of spiking activity to understand the pathophysiology of PD. Despite the point process nature of neuronal spiking activity, point process...
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