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Chemokines are small proteins that regulate leukocyte trafficking. They are important for development of tumors, because many chemokines are produced by tumor cells and attract leukocytes that contribute to malignancy. In addition, chemokines also act directly on tumor cells. In particular CXCL12 (SDF-1), and its receptor CXCR4, are required for metastasis of lymphoma and carcinoma cells. CXCL12 triggers...
CXCR4, CCR7 and CCR10 chemokine receptors are known to be involved in melanoma metastasis. Our goal was to compare the relative intratumoral mRNA expression of these receptors with that of their corresponding chemokine ligands, CXCL12, CCL19, CCL21, and CCL27 across the full spectrum of human melanoma progression: thin and thick primary melanomas, as well as “in transit”, lymph node, and distant metastases...
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