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Kaempferol (K), a flavonol, is known to have anti-osteoclastogenic effect. We here show that K, from 0.2 to 5.0μM, increased mineralized nodules in rat primary osteoblasts. K also significantly attenuated adipocyte formation from bone marrow cells (BMCs). A single oral dose of 1mg/kg body weight of K in Sprague–Dawley (180–200g) rats resulted in a peak serum level of 2.04±0.8nM in 30min (T max...
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