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Dilated cardiomyopathy (DCM) is typically defined by left ventricular dilation and systolic dysfunction in the absence of a clear precipitant. Idiopathic disease is common; up to 50% of patients with DCM have no cause found despite imaging, genetic and biopsy assessments. Treatment remains focused on managing symptoms, reducing the risk of sudden cardiac death and ameliorating the structural and electrical...
MicroRNAs (miRNAs) are about 20–22 nucleotide conserved non-coding RNA molecules that post-transcriptionally regulate gene expression by targeting the 3′-untranslated region of specific messenger RNAs (mRNAs) for degradation or translational repression. During the last two decades, miRNAs have emerged as criticalregulators of a range of biological processes including immune cell lineage commitment,...
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