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Rationale Cigarette smoking remains the leading cause of preventable morbidity and mortality in the USA, although only 3–5 % of quitters are successful for 6–12 months. Stress during abstinence increases the likelihood of relapse to smoking. We recently reported that repeated stress during abstinence from operant nicotine self-administration (SA) amplifies the reacquisition of nicotine SA and affects...
Rationale Quitting smoking is often very challenging, leading to frequent relapse. Exposure to acute and chronic stress during abstinence increases the likelihood of relapse to smoking. In rodents, stress acutely reinstates nicotine seeking after extinction of nicotine self-administration (SA). However, whether reacquisition of nicotine taking is amplified by chronic stress during abstinence from...
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