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Quinolactacins are novel fungal alkaloids that feature a quinolone‐γ‐lactam hybrid, which is a potential pharmacophore for the treatment of cancer and Alzheimer's disease. Herein, we report the identification of the quinolactacin A2 biosynthetic gene cluster and elucidate the enzymatic basis for the formation of the quinolone‐γ‐lactam structure. We reveal an unusual β‐keto acid (N‐methyl‐2‐aminobenzoylacetate)...
Quinolactacins are novel fungal alkaloids that feature a quinolone‐γ‐lactam hybrid, which is a potential pharmacophore for the treatment of cancer and Alzheimer's disease. Herein, we report the identification of the quinolactacin A2 biosynthetic gene cluster and elucidate the enzymatic basis for the formation of the quinolone‐γ‐lactam structure. We reveal an unusual β‐keto acid (N‐methyl‐2‐aminobenzoylacetate)...
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