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Impairments in cognitive and locomotor functions usually occur with advanced age, as do changes in brain volume. This study was conducted to assess changes in brain volume, cognitive and locomotor functions, and oxidative stress levels in middle- to late-aged rats. Forty-four male Sprague-Dawley rats were divided into four groups: 14, 18, 23, and 27months of age. 1H magnetic resonance imaging (MRI)...
The human brain atrophies with aging. By investigating the morphological change of brain structure and comparing with the deformation of normal aging, we can diagnose the cerebral diseases such as Alzheimer's diseases, Perkinson disease, etc. Magnetic resonance imaging (MRI) is a good diagnostic tool because it is non-invasive to the human body, and it can take the thin-sectional images with high...
We examined the associations of current alcohol consumption with brain morphometric measures in a healthy, community-dwelling cohort. Cranial T1-weighted 3D-structural MRI scans were obtain in 383 adults (men=211) aged 60–64 years, randomly selected form the larger PATH Through Life study. Voxel-based morphometric analyses were applied to detect regional gray matter and white matter volume changes...
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