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Millions of humans are exposed occupationally and environmentally to lead, mercury and cadmium compounds. Mercury compounds are less abundant but some of them belong to the most toxic chemicals which are known. We evaluated the literature to find out if these metals act in humans as genotoxic carcinogens and if their health effects can be predicted by use of micronucleus (MN) assays with lymphocytes...
Lead may be absorbed following inhalation or ingestion and is stored primarily in bone; elimination is predominantly renal. Lead is toxic to most organ systems through mechanisms that involve complexing with important functional chemical groups or substitution of essential metal ions. Management involves exposure avoidance and in more severe cases, chelation therapy with either sodium calcium edetate...
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