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The effects of choline on α4β4 nicotinic acetylcholine receptors, expressed in Xenopus oocytes, were investigated using the two-microelectrode voltage clamp technique. Particular attention was paid to the interaction between the effects of acetylcholine and choline. Choline was a low-affinity agonist of α4β4 receptors with an efficacy of 10% as compared to acetylcholine. Responses evoked by 1 μM acetylcholine...
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