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To compute extracellular potentials from transmembrane potentials an elliptic boundary-value problem must be solved. This must be done at a spatial resolution of 0.2 mm or better to avoid artefacts in the form of large spikes before and after major deflections. For macroscopic heart models, this leads to very large linear systems. Artefacts in low-resolution solutions are related to the restriction...
Echocardiography is a commonly-used, safe, and noninvasive method for assessing cardiac dysfunction and related coronary artery disease. The analysis of echocardiograms, whether visual or automated, has traditionally been hampered by the presence of ultrasound artifacts, which obscure the moving myocardial wall. In this study, a novel method is proposed for tracking the endocardial surface in 3D ultrasound...
Recent studies demonstrated that the vulnerable window was wider when the premature beat was initiated in the endocardium than in the epicardium. Because acute ischemia causes extensive electrical remodeling to the myocardium, we sought to determine if the same disparity of vulnerability due to the location of premature beat existed in acute ischemia. A numerical model that could reproduce the three...
Despite over a century's study, the trigger mechanisms of cardiac arrhythmias are poorly understood. Modern experimental methods do not provide sufficient temporal and spacial resolution to trace the development of fibrillation in samples of cardiac tissue, not to mention the heart in vivo. Computer simulations of electrical activity in cardiac tissue offer increasingly detailed insight into these...
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