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To compute extracellular potentials from transmembrane potentials an elliptic boundary-value problem must be solved. This must be done at a spatial resolution of 0.2 mm or better to avoid artefacts in the form of large spikes before and after major deflections. For macroscopic heart models, this leads to very large linear systems. Artefacts in low-resolution solutions are related to the restriction...
The aim of this study was to investigate sex and age related differences in drug induced QT prolongation by dofetilide under reduced repolarization reserve in simulated ventricular cells. Left ventricular endocardial action potentials were simulated using a modified Luo Rudy model. Sex, age and regional differences in currents ICaL, IKr, IKs, and Ito were incorporated into the model by modifying the...
In this work we present a new electromechanical cardiac myocyte model tailored to reproduce the electrical and force generating activities of human ventricular myocytes. The model was created by coupling two existing models: the ten Tusscher electrophysiology model and the Rice myofilament mechanics model. The parameters of the new model were adjusted in order to replicate the available experimental...
The Dominant T-wave (DTW) offers an overall view of the venticular repolarization as it reflects the first-order derivative of the transmembrane potential of the myocytes during repolarization (TMPR). DTW can be estimated from the analysis of surface T-waves, which are modeled as a linear combination of DTW and its derivatives. Usually, the contribute of the DTW dominates but, when dispersion of the...
The role that sarcoplasmic reticulum (SR) luminal Ca2+ concentration plays in regulating ryanodine receptors (RyRs) is considered to be very important in process of cardiac excitation-contraction coupling. Here we developed a multi-scale mathematical model by coupling a two-dimensional spatio-temporal Ca2+ reaction-diffusion model with an action potential model of the ventricular myocyte. The simulation...
Despite over a century's study, the trigger mechanisms of cardiac arrhythmias are poorly understood. Modern experimental methods do not provide sufficient temporal and spacial resolution to trace the development of fibrillation in samples of cardiac tissue, not to mention the heart in vivo. Computer simulations of electrical activity in cardiac tissue offer increasingly detailed insight into these...
A mathematical model of the action potential (AP) of human ventricular cell is constructed and used in simulation studies of Brugada syndrome. The model is based on Luo-Rudy model, and refined by recent experimental data on major ionic currents, and the formulations of ten Tusscher et al are also introduced into our model. The results show that the endocardial and midmyocardial cells AP have little...
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