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The aim of this work was to study the influence of pore KCNH2 mutation on the effects of dofetilide. Markovian models of G604S/WT mutation and dofetilide have been introduced in guinea pig ventricular cellular model. The effects of this pore mutation affecting this channel were analyzed. The G604S/WT mutation accelerates the inactivation and recovery from inactivation. Using this mutated cellular...
The sensitivity of hepatoma cells to total aqueous extract(TAE) from Artemisia argyi was investigated. HepG2 cells were treated with the extract at the concentrations of 17.5 mg(Artemisia argyi)/ml, 35 mg(Artemisia argyi)/ml, and 70mg(Artemisia argyi)/ml. Inverted microscope observation found that the total aqueous extract induced cell shrinkage after 12h, and ultimately cell death after persistent...
The nightshade (Solanum nigrum Linn.) has been widely used in Chinese traditional medicine as a remedy for the treatment of digestive system cancer. The anti-tumor activity of solanine, a steroid alkaloid isolated from the nightshade has been demonstrated. To observe the effect of antitumor and mechanism of solanine. The MTT assay was used to evaluate the IC50 on the 3 digestive system tumor cell...
Thalidomide is an anti-inflammatory and immunomodulatory drug that is the treatment of choice for erythema nodosum leprosum (ENL), an inflammatory cutaneous and systemic complication of multibacillary leprosy. Its use in leprosy and other conditions is controversial due to its teratogenic effects. Fifty years after the development of thalidomide, its action mechanism is still not well understood....
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