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The interaction of granulosa cells (GCs) with oocytes is important to regulate follicle development. The exogenous melatonin promoting the maturation of oocytes by GCs has been approved in pig, however, the transcriptome profile and the functions of the genes regulated by melatonin in GCs have not yet to be fully characterized. In this study, we found melatonin could stimulate the synthesis of estradiol...
During the last years, anti-Müllerian hormone (AMH) has been transformed into a “hot issue” of Reproductive Medicine, as it has attracted the attention of many research groups and has found considerable clinical applications. In this review, we have summarized available evidence on possible roles of AMH in women with polycystic ovary syndrome (PCOS). We have arranged the material into three sections...
Objective: To test the hypothesis that activin A promotes in vitro human oocyte meiotic maturation while inhibiting steroid secretion by nonluteinized antral granulosa cells.Design: Prospective randomized controlled study.Setting: A university medical center.Patient(s): Nine women ranging in age from 31-44 years who were undergoing oophorectomy for nonovarian pathology.Intervention(s): Analysis of...
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