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An important issue in epilepsy research is to understand the structural and functional modifications leading to chronic epilepsy, characterized by spontaneous recurrent seizures, after initial brain insult. To address this issue, we recorded and analyzed electroencephalography (EEG) and quantitative magnetic resonance imaging (MRI) data during epileptogenesis in the in vivo mouse model of Medial Temporal...
Thalamus and its interaction with cerebral cortex are considered essential in the generation and propagation of spike and wave discharge (SWD). Our objective is to evaluate the spontaneous functional connectivity between the thalamus and cerebral cortex in absence epilepsy. We use the resting-state fMRI to determine the whole brain functional connectivity with the mediodorsal thalamic nucleus (MDTN)...
The present study was aimed at investigating the accuracy of electric source reconstruction in the presurgical evaluation of epilepsy patients. Spontaneous EEG activity of 14 patients with focal intracerebral epileptogenic lesions was analyzed by source reconstruction based on high-resolution EEG (64-channel system) and a boundary element method head model accounting for the individual head anatomy...
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