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Progress toward a prototype MEMS gas chromatograph (muGC) designed for analyzing complex mixtures of volatile organic compounds (VOC) in breath is described. This muGC, named SPIRON, integrates a multi-stage preconcentrator/injector, a dual-microcolumn separation module, and a chemiresistor array detector with commercial minivalves and a minipump. Here, we describe results showing thermal control...
A new strategy is developed for a gene signature search proceeding from a biological basis in analyzing microarray databases. The procedure involves a combination of known and original methods for correlation, statistical, and network analysis. The application of the strategy to lung adenocarcinoma resulted in a 5-gene signature, which included four genes not associated earlier with lung adenocarcinoma...
Cross-study validation and combined analysis of microarray data is critical in genomic analysis. With so much genetic expression data being produced by microarrays in the study of cancer, knowing the extent to which these studies agree can provide valuable insight. Researchers from Johns Hopkins University, Baltimore used Pearson correlation coefficient to develop a system for performing cross-study...
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