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Supplementation of domestic animals with n−3 polyunsaturated fatty acids (n−3 PUFA) is becoming an accepted practice to improve the nutritional quality of lipids in animal products (e.g., meat, milk, eggs). However, by increasing the proportion of n−3 PUFA in plasma, this nutritional strategy also enhances its susceptibility to lipoperoxidation which has been implicated in the deterioration of many...
The aim of this study was to investigate the effect of peroxisome proliferator activated receptors alpha agonist, fenofibrate, on the level of oxidative stress, total antioxidant capacity, and plasma paraoxonase 1 (PON1) activity in the rat. The adult male Wistar rats received fenofibrate for 7 days. The drug was added to food at concentrations 0.005%, 0.05% and 0.5%, which corresponded to doses of...
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