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Poly(glycerol sebacate) (PGS) has become one of the most promising new tissue engineering scaffold materials-of-construction. We hypothesized that the lipase inhibitor Orlistat might be suitable for inhibiting lipase-mediated PGS degradation. Here we investigated whether Orlistat can: (1) be physically transported into PGS using 70% (v/v) ethanol in water as a carrier, (2) be stably entrapped within...
Nanocomposites of poly(lactic acid) (PLA) reinforced with cellulose whiskers highly dispersed with poly(ethylene glycol) (PEG) were prepared for the first time. The composites obtained by solvent casting methods from N, N-Dimethylacetamide (DMAc) were characterized by mechanical testing, fourier transform infrared spectroscopy (FT-IR), water absorption and biodegrade in simulated body fluid (SBF)...
A novel nano-hydroxyapatite/multi-(amino acid) copolymer (n-HA/MACP) composite was prepared by in situ polymerization and characterized by FT-IR XRD, mechanical measurement, in vitro degradation experiments and cell growth behavior. FT-IR and XRD results showed that the composite was composed of n-HA and an amide linkage structure and hydrogen bond was formed between n-HA and the copolymer. The composite...
In the present study, poly (D, L-lactic acid) (PDLLA) modified genipin-cross-linked chitosan/gelatin scaffolds loaded icariin were prepared. The scaffolds with genipin cross-linking were fabricated with lyophilization, and then were immersed into the 2.5%, 5.0%, and 7.5% PDLLA-dichloromethane solutions. Thus the PDLLA modified genipin-cross-linked scaffolds were obtained after evaporating the solvent...
The present work examines porous scaffolds preparation methods by combining salt leaching, gas forming, solvent evaporation and phase separation techniques. The scaffolds are intended for bone tissue regeneration. It aims to combine the biodegradability of poly (epsiv-caprolactone) (PCL) with the osteoconductive properties of hydroxylapatite (HA) in order to create a composite which acts as a temporary...
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