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In order to image the brain of live animals, a system is required to position an animal's head under the microscope while keeping it anesthetized and warm. Most available heating systems are thick and uneven, limiting the number of microscopes they can be used with. Most available stereotaxic devices are bulky and have difficulty aligning mice across imaging sessions. We have developed an in vivo...
We demonstrate that quantitative phase imaging (QPI) can detect amyloid plaques in the brain of Alzheimer's disease (AD). Comparing QPIs and fluorescence images from wild-type and AD mice brains, we suggest that digital microscopic holography can be utilized for diagnosing AD.
3-photon microscopy at the long wavelength spectral windows is well suited for deep imaging within scattering biological tissues. In vivo 3-photon imaging of neuronal structure and function deep within an intact mouse brain is presented.
We demonstrate three-photon microscopy (3PM) at 1300-nm excitation for imaging neuronal activity as deep as layer-6 (L6) of adult mouse cortex using genetically-encoded calcium indicators. In vivo imaging of subcortical, GFP-labeled neurons is also demonstrated.
This paper describes a method to transplant neurospheroid network onto the rat brain. We first patterned the uniform sized neurospheroids on the PDMS microchamber, and cultured for 1-2 weeks. After 2-week culture, the neurospheroids tightly connected each other with extending their neuronal processes (e.g. dendrite, axons) and formed neuronal network. We realized that the neurospheroid network can...
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