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A major challenge in the elucidation of brain neurotransmitter events in vivo in the laboratory and in the operating room has been the development of methods to record neurotransmitters in the CNS on a second-by-second time scale. Microdialysis methods have been widely employed but are limited due to their inherent slow sampling rates (1-20 min) and poor exchange (~10-20%) of neurotransmitters. We...
Betacyanins from Portulaca oleracea markedly reversed the D-gal induced learning and memory impairment by behavioral tests. The activities of SOD, CAT, GPx and GR in D-galactose-treated mice were enhanced. Significant negative correlations were found between the latency to find the platform of mice and the activities of SOD, CAT GR and GPx in mice brain. These results suggest the neuroprotective effect...
Heroin addiction caused oxidative stress was testified for the first time in mice. After administered with heroin, mice not only showed decreased total antioxidant capacity as well as antioxidant enzymes such as, SOD, CAT and GPx in brain, but also include oxidative damage of DNA, protein and lipid. On the other hand, exogenous antioxidants could restrain the oxidative stress, even alleviate withdrawal...
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