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The surface-enhanced Raman scattering (SERS) method has great potential for the detection of Raman-active species, ranging from single molecules to biomolecules. In the last five years, various approaches have been developed to fabricate SERS-active substrates with high sensitivity using noble metal nanostructures via top-down, bottom-up, combination, or template-assisted routes. Nanostructured substrates...
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