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Nitric oxide (NO) is known to be involved in the immune response against a range of organisms. Little is known about the effects of nitric oxide in pneumococcal infections. We have now investigated the role of nitric oxide in local and systemic infections caused by Streptococcus pneumoniae in NOS2 deficient mice.Although a deficiency in NO does not affect survival of mice during pneumococcal pneumonia,...
Exposure of primary rat glial cells to heat inactivated Streptococcus pneumoniae, induced dose-dependent production of tumor necrosis factor α (TNFα), nitric oxide (NO) and prostaglandin E 2 (PGE 2 ). Concomitant addition of the bacterium and the synthetic glucocorticoid dexamethasone resulted in complete suppression of TNFα, NO and PGE 2 production. Pentoxifylline, a phosphodiesterase...
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