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Understanding the unique mechanical properties of living cells in general, and specifically those of metastatic cancer cells, can lead to major developments in treatment and prevention of diseases. We combine cell micromechanics measurements with cell biology techniques to elucidate the mechanical response of cells. We focus on cells with different metastatic potentials and their response to cytoskeletal...
We describe here a palpation-based needle insertion method for diagnostic biopsy and treatment of breast cancer. The mechanical palpation probe locates cancerous tissue from force information and reduces tissue displacement during needle insertion. We compared palpation-based needle insertion to normal needle insertion by numerical simulation of a breast tissue model and by experiments in vitro. The...
The noninvasive transient thermal clearance method provides a means for measuring regional blood flow, by measuring the rate of the skin temperature increase after insulating it from its surroundings. The method provides an absolute assessment of tissue blood flow, as opposed to measuring the temperature of the uncovered skin, as is done by thermography. Skin blood flow measured in the areolas of...
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