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Phage display provides a methodology for obtaining fully human antibodies directed against human transforming growth factor-β (TGFβ) suitable for the treatment of fibrotic disorders. The strategy employed was to isolate a human single chain Fv (scFv) fragment that neutralises human TGFβ2 from a phage display repertoire, convert it into a human IgG4 and then determine its TGFβ binding and neutralisation...
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