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Gene therapy has been considered to be a powerful approach for the prevention and/or treatment of a variety of diseases from genetic disorders, infections, to cancer. The success of gene therapy in the clinic is largely limited currently, mainly due to the lack of safe and efficient delivery vectors. Despite the high transfection efficiency, viral vectors encounter the vital toxicity issues and production...
Intracellular-acting therapeutic proteins offer a promising clinical alternative to extracellular-acting agents, but are limited in efficacy by their low permeability into the cell cytoplasm. We have developed a nanoparticle (NP) composed of lipid (DOTAP/DOPE) and apolipoprotein (APOA-I) to mediate the targeted delivery of intracellular-acting protein drugs to non-small cell lung tumors. NPs were...
EGFR serves as an important therapeutic target because of its over-expression in many cancers. In this study, we investigated a peptide-based therapy aimed at blocking intracellular protein–protein interactions during EGFR signaling and evaluated a targetable lipid carrier system that can deliver peptides to intracellular targets in human cancer cells. EEEEpYFELV (EV), a nonapeptide mimicking the...
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